Hydrochloric Acid → HCID 68456018, compound

HRID 502463Notes

Reaction equation

HRID 502463 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[CH:18]=[N:19][C:20]([C:24]#[N:25])=[C:21]([CH3:23])[CH:22]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[C:24]([C:20]1[C:21]([CH3:23])=[CH:22][C:17]([C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:16])=[CH:18][N:19]=1)#[N:25]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68457923HCID 68457923, compound

Product 1

HCID 68456018HCID 68456018, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To the above prepared 4-[(6-cyano-5-methyl-pyridine-3-carbonyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester (0.363 g, 1.05 mmol), dissolved in 3 ml of dioxane, was added 5.27 ml of 4N HCl (dioxane) and the resulting suspension stirred at ambient temperature for another h. Careful evaporation left 0.375 g of the title compound as hydrochloride as off-white crystals.

Workup

  1. customCareful evaporation
  2. waitleft 0.375 g of the title compound as hydrochloride as off-white crystals

Sources & evidence

ORD record
ord-971a9e1a85cd4732b5a379f21470bf36
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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