Hydrochloric Acid → HCID 68459489, compound

HRID 502499Notes

Reaction equation

HRID 502499 reaction equation
[ClH:1].Cl.[CH3:3][N:4]([CH2:6][CH:7]1[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)([OH:17])[CH2:15][CH2:14][C:9]2(OCC[O:10]2)[CH2:8]1)[CH3:5]>O1CCCC1.O>[ClH:1].[CH3:5][N:4]([CH2:6][CH:7]1[C:16]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)([OH:17])[CH2:15][CH2:14][C:9](=[O:10])[CH2:8]1)[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68460405HCID 68460405, compound

Product 1

HCID 68459489HCID 68459489, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

215 ml of hydrochloric acid (32%, excess) were added rapidly at 0° C. to a solution of 7-dimethylaminomethyl-8-phenyl-1,4-dioxa-spiro[4.5]decan-8-ol hydrochloride (85 g, 259 mmol) in tetrahydrofuran/water mixture, and stirring was then carried out for 16 hours at RT. The resulting colorless solid was filtered out with suction and dried. 47.5 g (65%) of the product were obtained.

Workup

  1. filtrationThe resulting colorless solid was filtered out with suction
  2. customdried

Sources & evidence

ORD record
ord-e5e3cea750cc477fa2afea5eb6abe909
Source dataset
uspto-grants-2010_08
Patent number
US07776848B2

Reaction notes

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