反应详情

温度

60 °C

A solution of benzo[b]thiophen-3-yl-acetic acid (6.0 g, 31.2 mmol) in 40 ml of tetrahydrofuran was added dropwise at RT to a suspension of lithium alanate (1.54 g, 41 mmol) in 35 ml of tetrahydrofuran. The mixture was stirred for 60 minutes at 60° C., and then excess alanate was hydrolysed with ethanol. The mixture was suction-filtered over Kieselguhr and the solvent was removed in vacuo. The product was obtained in the form of a yellowish oil in a yield of 5.1 g (92%).

1. filtrationThe mixture was suction-filtered over Kieselguhr
2. customthe solvent was removed in vacuo
3. customThe product was obtained in the form of a yellowish oil in a yield of 5.1 g (92%)