HRID502534

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(=O)N(C[C@H]1CN(c2ccc(N3Cc4cn(C)nc4C3)c(F)c2)C(=O)O1)C(=O)OC(C)OP(=O)(OC(C)(C)C)OC(C)(C)C

HCID68464915

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N(C[C@H]1CN(c2ccc(N3Cc4cn(C)nc4C3)c(F)c2)C(=O)O1)C(=O)OC(C)OP(=O)(O)O

HCID24768948

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of 17b (1 equiv) in dichloromethane is added TFA (3 equiv) and the reaction mixture is stirred at rt for 3 h. The reaction mixture is concentrated in vacuo, and purified directly by HPLC (C-18 column, 10-100% gradient elution, MeCN:H2O) to give the title compound. Theoretical MS 542 (M+1)+

WORKUP

后处理

concentrationThe reaction mixture is concentrated in vacuo
custompurified directly by HPLC (C-18 column, 10-100% gradient elution, MeCN:H2O)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-acbf5d09b96d48c09bc61f34d8060d01
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07776855B2
来源说明: uspto-grants-2010_08

反应 SMILES

C([O:5][P:6]([O:41]C(C)(C)C)([O:8][CH:9]([O:11][C:12](=[O:40])[N:13]([C:37](=[O:39])[CH3:38])[CH2:14][C@@H:15]1[O:19][C:18](=[O:20])[N:17]([C:21]2[CH:26]=[CH:25][C:24]([N:27]3[CH2:34][C:33]4[C:29](=[N:30][N:31]([CH3:35])[CH:32]=4)[CH2:28]3)=[C:23]([F:36])[CH:22]=2)[CH2:16]1)[CH3:10])=[O:7])(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[P:6]([O:8][CH:9]([O:11][C:12](=[O:40])[N:13]([C:37](=[O:39])[CH3:38])[CH2:14][C@@H:15]1[O:19][C:18](=[O:20])[N:17]([C:21]2[CH:26]=[CH:25][C:24]([N:27]3[CH2:34][C:33]4[C:29](=[N:30][N:31]([CH3:35])[CH:32]=4)[CH2:28]3)=[C:23]([F:36])[CH:22]=2)[CH2:16]1)[CH3:10])([OH:7])([OH:41])=[O:5]