反应详情

A solution of tert-butyl 3-(2-(benzo[d]isothiazol-3-ylamino)ethylcarbamoyl)piperidine-1-carboxylate (360 mg, 0.89 mmol) in trifluoroacetic acid (2 mL) and dichloromethane (2 mL) was cooled to 0° C. and stirred for 2 h. The reaction mixture was then concentrated under reduced pressure and lyophilized to yield N-(2-(benzo[d]isothiazol-3-ylamino)ethyl)piperidine-3-carboxamide as a yellow oil (265 mg). MW=304 confirmed by LC-MS, tr=2.39 min (Method B) MH+=305.

1. concentrationThe reaction mixture was then concentrated under reduced pressure