Benzenamine hydrochloride (1:1) → HCID 86611051, compound

HRID 502613Notes

Reaction equation

HRID 502613 reaction equation
[CH:1]([C:5]1[C:6]([CH3:20])=[CH:7][C:8]([I:19])=[C:9]([CH:18]=1)[O:10][C:11](=[CH:14][N:15]([CH3:17])C)[C:12]#[N:13])=[CH:2][CH:3]=[CH2:4].Cl.N[C:23]1[CH:28]=[CH:27]C=[CH:25][CH:24]=1>C(O)C>[CH:1]([C:5]1[C:6]([CH3:20])=[CH:7][C:8]([I:19])=[C:9]([CH:18]=1)[O:10][C:11](=[CH:14][NH:15][C:17]1[CH:27]=[CH:28][CH:23]=[CH:24][CH:25]=1)[C:12]#[N:13])=[CH:2][CH:3]=[CH2:4]

Participants

4

Reactant 2

HCID 8870Benzenamine hydrochloride (1:1)HCID 86611052HCID 86611052, compound

Product 1

HCID 86611051HCID 86611051, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To the crude crude 2-(5-buta-1,3-dienyl-2-iodo-4-methyl-phenoxy)-3-dimethylamino-acrylonitrile of step 3 was added aniline hydrochloride (2.54 g, 19.59 mmol) and ethanol (25 mL). The mixture was heated to reflux for 16 hours under nitrogen atmosphere. The mixture was cooled and concentrated under reduced pressure to yield crude 2-(5-buta-1,3-dienyl-2-iodo-4-methyl-phenoxy)-3-phenylamino-acrylonitrile, which was used in the same flask directly in the following step.

Workup

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 16 hours under nitrogen atmosphere
  3. temperatureThe mixture was cooled
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-9df37a7108b546bfa31861217260f002
Source dataset
uspto-grants-2010_08
Patent number
US07776872B2

Reaction notes

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