反应详情

Into a 100 mL round bottom flask was placed 5-phenylfuro[2,3-d]benzopyrimidin-4 (3H)-one (1.12 g, 5.3 mmol) and benzene (75 mL). The flask was equipped with a stir bar, reflux condenser, and Dean-Stark trap, and the reaction was allowed to reflux with stirring for 1 hour azeotropically removing the water formed. The reaction was cooled to room temperature. Phosphorus oxychloride was added (2.43 g, 15.9 mmol) dropwise, the flask equipped with a reflux condenser and the reaction was heated at reflux for 20 hours with stirring.

1. customInto a 100 mL round bottom flask was placed
2. customThe flask was equipped with a stir bar
3. temperaturereflux condenser
4. temperatureto reflux
5. customazeotropically removing the water
6. customformed
7. customthe flask equipped with a reflux condenser
8. temperaturethe reaction was heated
9. temperatureat reflux for 20 hours
10. stirringwith stirring