反应详情

温度

120 °C

A mixture of 69 (150 mg, 0.86 mmol), 1,3-dithiolan-2-yl-methylamine (240 μL, 1.78 mmol), and DIEA 0.31 mL (1.78 mmol) in 1-butanol (1 mL) was heated to 120° C. for 2 h. After cooling, the reaction mixture was concentrated, and the residue was purified by silica gel column chromatography, affording 110 (121 mg). LCMS and 1HNMR are identical with the product obtained from method 1.

1. temperatureAfter cooling
2. concentrationthe reaction mixture was concentrated
3. customthe residue was purified by silica gel column chromatography