Phosphorus oxychloride → 4-Chloro-6-iodo-5-phenyl-furo[2,3-d]pyrimidine

Participants

Reaction Steps

163 (0.8 g, 2.35 mmol) was refluxed in phosphorous oxychloride (12 mL) for 90 minutes. The reaction mixture was concentrated and diluted with ice-cold water, extracted with dichloromethane. The organic layer was washed with water and dried over MgSO4. The organic solvent upon concentration provided a pale solid which on trituration with MeOH provided 164 as a pale solid (0.57 g, 68%).

Provenance & Evidence