反应详情

163 (0.8 g, 2.35 mmol) was refluxed in phosphorous oxychloride (12 mL) for 90 minutes. The reaction mixture was concentrated and diluted with ice-cold water, extracted with dichloromethane. The organic layer was washed with water and dried over MgSO4. The organic solvent upon concentration provided a pale solid which on trituration with MeOH provided 164 as a pale solid (0.57 g, 68%).

1. concentrationThe reaction mixture was concentrated
2. additiondiluted with ice-cold water
3. extractionextracted with dichloromethane
4. washThe organic layer was washed with water
5. dry with materialdried over MgSO4
6. concentrationThe organic solvent upon concentration
7. customprovided a pale solid which on trituration with MeOH