HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 4-[(S)-(tetrahydrofuran-2-yl)-methyl]amino-6-iodo-5-phenyl-furo[2,3-d]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Chloro-6-iodo-5-phenyl-furo[2,3-d]pyrimidine | HCID 58603266 | — |
| Reactant | (S)-(tetrahydrofuran-2-yl)-methylamine | HCID 66683780 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[(S)-(tetrahydrofuran-2-yl)-methyl]amino-6-iodo-5-phenyl-furo[2,3-d]pyrimidine | HCID 11596953 | — |
Reaction Steps
A solution of 164 (550 mg, 1.54 mmol), (S)-tetrahydrofuran-2-yl-methylamine (190 μL, 1.85 mmol), and DIEA (401 μL, 2.3 mmol) in DMF (4 mL) was heated to 100° C. for 1 h. The reaction mixture was diluted with water, the precipitated solid was filtered and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07776867B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-0ecbbc64efff452cb4b51cd282f21381 |
| Source note | uspto-grants-2010_08 |