反应详情

A solution of 164 (550 mg, 1.54 mmol), (S)-tetrahydrofuran-2-yl-methylamine (190 μL, 1.85 mmol), and DIEA (401 μL, 2.3 mmol) in DMF (4 mL) was heated to 100° C. for 1 h. The reaction mixture was diluted with water, the precipitated solid was filtered and dried.

1. filtrationthe precipitated solid was filtered
2. customdried