反应详情

温度

150 °C

A stirred mixture of 4-amino-5,6-diphenylfuro[2,3-d]pyrimidine (100 mg, 0.34 mmol), 2-bromomethyl-1,3-dioxolane (116 mg, 0.69 mmol) and sodium hydroxide granules (42 mg, 1.05 mmol) in DMF (1.5 mL) was heated at 150° C. for 1 hour. The resulting mixture was filtered and purified by preparative HPLC to give a beige solid (73 mg). 1H NMR (CDCl3): 8.50 (1H, s), 7.62-7.49 (7H, m), 7.32-7.25 (3H, m), 5.70 (1H, br s), 5.00 (1H, br s), 3.85-3.63 (6H, m). LC/MS: 374 (MH+).

1. filtrationThe resulting mixture was filtered
2. custompurified by preparative HPLC