反应详情

1-methoxy-3-methyl-2-nitro-4-(trifluoromethyl)benzene (258 mg, 1.10 mmol), methanol (11.0 mL), and palladium on carbon (77.4 mg) were combined in a N2-purged round bottom flask. A balloon containing H2 was affixed to the flask, and the solution was saturated with H2 for 2 minutes. The reaction mixture was allowed to stir under H2 atmosphere for 12 hrs. Upon completion, as judged by LCMS, the reaction mixture was filtered through a plug of Celite and the solvent was removed in vacuo to afford 6-methoxy-2-methyl-3-(trifluoromethyl)benzenamine. MS m/z=206 [M+H]+. Calc'd for C9H10F3NO: 205.

1. custompurged round bottom flask
2. additionA balloon containing H2
3. filtrationthe reaction mixture was filtered through a plug of Celite
4. customthe solvent was removed in vacuo