2-Morpholinoethylamine → HCID 59427845, compound

HRID 502733Notes

Reaction equation

HRID 502733 reaction equation
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:5]=1[C:13]([F:16])([F:15])[F:14])=[C:2]=[O:3].[O:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][NH2:25])[CH2:19][CH2:18]1>C1C=CC=CC=1>[O:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][NH:25][C:2]([NH:1][C:4]2[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:5]=2[C:13]([F:14])([F:15])[F:16])=[O:3])[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 50839754-Nitro-2-(trifluoromethyl)phenyl isocyanate

Product 1

HCID 59427845HCID 59427845, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 1-isocyanato-4-nitro-2-(trifluoromethyl)benzene (339 μL, 2.21 mmol, 1.0 equiv) in benzene (3.0 mL), was added 2-morpholinoethanamine (316 mg, 2.43 mmol, 1.0 equiv). The resulting precipitant was filtered and washed with hexanes to provide 1-(2-morpholinoethyl)-3-(4-nitro-2-(trifluoromethyl)phenyl)urea, which was advanced without further purification. MS (MH+) 363; Calculated for C14H17F3N4O4: 362.1

Workup

  1. filtrationThe resulting precipitant was filtered
  2. washwashed with hexanes

Sources & evidence

ORD record
ord-1d7b75a8262043b5a46c6f5c567a966d
Source dataset
uspto-grants-2010_08
Patent number
US07776869B2

Reaction notes

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