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HRID50292

反应详情

EQUATION

反应方程式

HRID 50292 的结构方程式

REACTANTS

反应物

2
结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：CCOC(=O)CCN(C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C)c1ccccc1F.Cl
HCID18412542

未命名化合物

PRODUCTS

生成物

1
结构：Cn1c(CNc2ccc(C(=N)N)cc2)nc2cc(C(=O)N(CCC(=O)O)c3ccccc3F)ccc21
HCID18412330

未命名化合物

收率 45%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO.ClCCl
溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

PROCEDURE

实验过程

Prepared analogously to Example 26 from 1-methyl-2-[N-(4-amidinophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-fluorophenyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and sodium hydroxide solution. Yield: 45% of theory, C26H25FN6O3 (488.5); Rf value: 0.05 (silica gel; dichloromethane/ethanol=4:1); EKA mass spectrum: (M+H)+=489; (M+H+Na)++=267; (M+2H)++=256.