Hydrochloric Acid → HCID 58970790, compound

HRID 502941Notes

Reaction equation

HRID 502941 reaction equation
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([C:17](=[O:19])[CH3:18])[CH:13]=2)[N:8]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=2)[CH:7]=1)=[O:5])C.[OH-].[Na+].O.Cl>C(O)C>[F:27][C:24]1[CH:23]=[CH:22][C:21]([CH2:20][N:8]2[C:9]3[C:14](=[CH:13][C:12]([C:17](=[O:19])[CH3:18])=[CH:11][CH:10]=3)[C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7]2)=[CH:26][CH:25]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 68445078HCID 68445078, compound

Product 1

HCID 58970790HCID 58970790, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of compound 9 (0.46 g, 1.3 mmol) and 20% aqueous NaOH (4.3 mL) in ethanol (3 mL) was stirred for 18 hours at room temperature, then was poured into water (100 mL) and treated with 1N HCl until pH 3. The precipitate was filtered, washed with dry ethanol and light petroleum ether to give compound 12 (0.36 g, 88%); mp 206-208° C. (washed with dry ethanol).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with dry ethanol and light petroleum ether

Sources & evidence

ORD record
ord-2019cc7caa50413f8712b41abdae35e5
Source dataset
uspto-grants-2010_08
Patent number
US07776883B2

Reaction notes

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