Benzyl Bromide → HCID 68465479, compound

HRID 502955Notes

Reaction equation

HRID 502955 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8]2)=[CH:3][CH:2]=1.[CH2:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(#N)C>[CH2:17]([N:1]1[CH2:6][CH2:5][CH:4]([C:7]2([C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH2:11][CH2:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 53750208HCID 53750208, compound

Product 1

HCID 68465479HCID 68465479, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Ethyl 1-pyridin-4-ylcyclopentanecarboxylate and benzyl bromide were reacted in acetonitrile under heating. The residue obtained by subjecting the reaction solution to evaporation under reduced pressure, triethylamine and platinum oxide were reacted in ethanol under a hydrogen atmosphere to obtain ethyl 1-(1-benzylpiperidin-4-yl)cyclopentanecarboxylate.

Workup

  1. temperatureunder heating
  2. customThe residue obtained
  3. customto evaporation under reduced pressure, triethylamine and platinum oxide
  4. customwere reacted in ethanol under a hydrogen atmosphere

Sources & evidence

ORD record
ord-3892a21d5c914053805c59f75c839f17
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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