Hydrazine hydrate (1:1) → HCID 68468821, compound

HRID 502959Notes

Reaction equation

HRID 502959 reaction equation
[CH3:1][C:2]1([CH3:14])[CH2:5][C:4]([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)([C:6](O)=[O:7])[CH2:3]1.C1C=C2[N:21]=[N:22]N(O)C2=CC=1.O.O.NN>C(#N)C>[CH3:1][C:2]1([CH3:14])[CH2:5][C:4]([C:9]2[S:10][CH:11]=[CH:12][CH:13]=2)([C:6]([NH:21][NH2:22])=[O:7])[CH2:3]1

Participants

5

Reactant 3

HCID 24654Hydrazine hydrate (1:1)HCID 27960291-Hydroxybenzotriazole hydrateHCID 65000123HCID 65000123, compound

Product 1

HCID 68468821HCID 68468821, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

3,3-Dimethyl-1-(2-thienyl)cyclobutanecarboxylic acid was reacted with HOBt monohydrate and WSC monohydrochloride in acetonitrile at room temperature. The above reaction solution was added dropwise to an acetonitrile solution of hydrazine monohydrate and the whole was reacted at 0° C. to obtain 3,3-dimethyl-1-(2-thienyl)cyclobutanecarbohydrazide.

Workup

  1. customThe above reaction solution
  2. customthe whole was reacted at 0° C.

Sources & evidence

ORD record
ord-40731e8630e2463baf1a73e53ec218cd
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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