Hydrazine hydrate (1:1) → 1-[(Tert-butoxycarbonyl)amino]cyclopentanecarbohydrazide

HRID 502960Notes

Reaction equation

HRID 502960 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]1([C:14]([O:16]C)=O)[CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].O.[NH2:19][NH2:20]>CO>[C:1]([O:5][C:6]([NH:8][C:9]1([C:14]([NH:19][NH2:20])=[O:16])[CH2:13][CH2:12][CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22997550Cyclopentanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester

Product 1

HCID 587651571-[(Tert-butoxycarbonyl)amino]cyclopentanecarbohydrazide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Methyl 1-[(tert-butoxycarbonyl)amino]cyclopentanecarboxylate and hydrazine monohydrate were reacted in methanol under heating to obtain 1-[(tert-butoxycarbonyl)amino]cyclopentanecarbohydrazide.

Workup

  1. temperatureunder heating

Sources & evidence

ORD record
ord-c3961a13cd634cc588e291667033c94b
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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