Diisobutylaluminumhydride → 2-[5-(2-Chlorophenyl)-4-methyl-1,2,4-triazol-3-yl]-2-methylpropanal

HRID 502973Notes

Reaction equation

HRID 502973 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([CH3:21])[C:10]([C:13]([CH3:20])([CH3:19])[C:14](OCC)=[O:15])=[N:11][N:12]=1.[H-].C([Al+]CC(C)C)C(C)C>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:9]([CH3:21])[C:10]([C:13]([CH3:19])([CH3:20])[CH:14]=[O:15])=[N:11][N:12]=1

Participants

4

Reactant 2

HCID 21225700DiisobutylaluminumhydrideHCID 68468476Ethyl 2-[5-(2-chlorophenyl)-4-methyl-1,2,4-triazol-3-yl]-2-methylpropanoate

Product 1

HCID 866162232-[5-(2-Chlorophenyl)-4-methyl-1,2,4-triazol-3-yl]-2-methylpropanal

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Ethyl 2-[5-(2-chlorophenyl)-4-methyl-1,2,4-triazol-3-yl]-2-methylpropanoate was reacted with diisobutylaluminum hydride in toluene at −78° C. to obtain 2-[5-(2-chlorophenyl)-4-methyl-1,2,4-triazol-3-yl]-2-methylpropanal.

Sources & evidence

ORD record
ord-279c9d7552724430a884f17002e5db37
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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