Acetic Anhydride → HCID 68471202, compound

HRID 503013Notes

Reaction equation

HRID 503013 reaction equation
[C:1]([O:4][C:5](=[O:7])[CH3:6])(=O)[CH3:2].[NH:8]([C:15]([C:18]1[N:19]([CH3:30])[C:20]([C:23]2[CH:28]=CC(O)=[CH:25][CH:24]=2)=[N:21][N:22]=1)([CH3:17])[CH3:16])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>N1C=CC=CC=1>[C:5]([O:4][C:1]1[CH:25]=[CH:24][C:23]([C:20]2[N:19]([CH3:30])[C:18]([C:15]([NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)([CH3:17])[CH3:16])=[N:22][N:21]=2)=[CH:28][CH:2]=1)(=[O:7])[CH3:6]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 136368368HCID 136368368, compound

Product 1

HCID 68471202HCID 68471202, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Acetic anhydride (37 μl) was added to a pyridine solution (1 ml) of 4-[5-(1-anilino-1-methylethyl)-4-methyl-4H-1,2,4-triazol-3-yl}phenol (60 mg), followed by stirring for 3 hours. After most of acetic anhydride and pyridine was removed by evaporation under reduced pressure, the residue was purified by thin layer chromatography (chloroform:methanol=9:1) to obtain 40 mg of 4-[5-(1-anilino-1-methylethyl)-4-methyl-4H-1,2,4-triazol-3-yl}phenyl acetate (white crystals).

Workup

  1. customAfter most of acetic anhydride and pyridine was removed by evaporation under reduced pressure
  2. customthe residue was purified by thin layer chromatography (chloroform:methanol=9:1)

Sources & evidence

ORD record
ord-57c798946fa54cd398b9e0ffdc652197
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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