Ethyl isocyanate → HCID 68466423, compound

HRID 503014Notes

Reaction equation

HRID 503014 reaction equation
C(N(CC)CC)C.[CH2:8]([N:10]=[C:11]=[O:12])[CH3:9].[NH:13]([C:20]([C:23]1[N:24]([CH3:35])[C:25]([C:28]2[CH:33]=[CH:32][C:31]([OH:34])=[CH:30][CH:29]=2)=[N:26][N:27]=1)([CH3:22])[CH3:21])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(Cl)(Cl)Cl>[CH2:8]([NH:10][C:11](=[O:12])[O:34][C:31]1[CH:32]=[CH:33][C:28]([C:25]2[N:24]([CH3:35])[C:23]([C:20]([NH:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)([CH3:22])[CH3:21])=[N:27][N:26]=2)=[CH:29][CH:30]=1)[CH3:9]

Participants

5

Reactant 3

HCID 8022Ethyl isocyanateHCID 8471TriethylamineHCID 136368368HCID 136368368, compound

Product 1

HCID 68466423HCID 68466423, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
60 °C

Procedure

Triethylamine and ethyl isocyanate were added to a chloroform solution (3 ml) of 4-[5-(1-anilino-1-methylethyl)-4-methyl-4H-1,2,4-triazol-3-yl}phenol (20 mg), followed by stirring at 60° C. for 3 hours. After concentration, a small amount of ethyl acetate was added to the residue and the resulting crystalline powder was filtered to obtain 4-[5-(1-anilino-1-methylethyl)-4-methyl-4H-1,2,4-triazol-3-yl}phenyl ethylcarbamate.

Workup

  1. concentrationAfter concentration
  2. additiona small amount of ethyl acetate was added to the residue
  3. filtrationthe resulting crystalline powder was filtered

Sources & evidence

ORD record
ord-54c7a865e6be4b2993c0feb429149fe2
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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