Chloroform → HCID 178465371, compound

HRID 503017Notes

Reaction equation

HRID 503017 reaction equation
C(Cl)(Cl)Cl.[CH3:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([C:13]2[NH:17][C:16]([C:18]3([C:23]4[S:24][CH:25]=[CH:26][CH:27]=4)[CH2:22][CH2:21][CH2:20][CH2:19]3)=[N:15][N:14]=2)[CH:7]=1.[CH2:28]([N:30]=[C:31]=[O:32])[CH3:29]>C(N(CC)CC)C>[CH2:28]([NH:30][C:31](=[O:32])[O:12][C:9]1[CH:10]=[CH:11][C:6]([CH3:5])=[CH:7][C:8]=1[C:13]1[NH:17][C:16]([C:18]2([C:23]3[S:24][CH:25]=[CH:26][CH:27]=3)[CH2:19][CH2:20][CH2:21][CH2:22]2)=[N:15][N:14]=1)[CH3:29]

Participants

5

Reactant 3

HCID 6212ChloroformHCID 8022Ethyl isocyanateHCID 178426842HCID 178426842, compound

Product 1

HCID 178465371HCID 178465371, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

A chloroform solution (2.7 ml) of 4-{4-methyl-[5-(1-(2-thienyl)cyclopentyl]-4H-1,2,4-triazol-3-yl}phenol (40 mg), triethylamine (103 μl), and ethyl isocyanate (57 μl) was heated at 60° C. for 5 hours. The solvent was removed by evaporation and a small amount of ethyl acetate was added to the residue. The resulting white solid was collected by filtration and washed with diethyl ether to obtain 4-{4-methyl-[5-(1-(2-thienyl)cyclopentyl]-4H-1,2,4-triazol-3-yl}phenyl ethylcarbamate (30 mg).

Workup

  1. customThe solvent was removed by evaporation
  2. additiona small amount of ethyl acetate was added to the residue
  3. filtrationThe resulting white solid was collected by filtration
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-24b2e220e0ed4d22a5ec2c2319e44784
Source dataset
uspto-grants-2010_08
Patent number
US07776897B2

Reaction notes

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