反应详情

0.7 g (1.1 mmol) of 1-methyl-2-[N-[4-(N-n-octyloxycarbonylamidino)phenyl]aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-methoxycarbonylethyl)amide was stirred in a mixture of 0.12 g (3.0 mmol) of sodium hydroxide, 5 mL of water, and 10 mL of methanol for one hour at room temperature. Then the mixture was diluted with 20 mL of water and adjusted to pH 6 with glacial acetic acid. Then about 5 mL of diethylether were added and the mixture was vigorously stirred for one hour. The product thus precipitated was suction filtered, washed with a little water, then with diethylether and dried. Yield: 80% of theory, C34H41N7O5 (627.8); EKA mass spectrum: (M+H)+=628; (M+H+Na)++=325.7; (M+Na)+=650; (M+2Na)++=337.7.

1. customThe product thus precipitated
2. filtrationfiltered
3. washwashed with a little water
4. dry with materialwith diethylether and dried