反应详情

Under ice-cooling, to a solution of 910 mg of 1H-5-indazolecarboxylic acid in 60 ml tetrahydrofuran was added an excess amount of a solution of diazomethane in diethyl ether, and the mixture was stirred at the same temperature for 1 hour. After removing the solvent by distillation, the residue was added with 50 ml of ethyl acetate, sequentially washed with saturated aqueous sodium hydrogencarbonate solution and brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 923 mg of the title compound as pale yellow crystals.

1. customAfter removing the solvent
2. distillationby distillation
3. additionthe residue was added with 50 ml of ethyl acetate
4. washsequentially washed with saturated aqueous sodium hydrogencarbonate solution and brine
5. dry with materialdried over anhydrous magnesium sulfate
6. customthe solvent was evaporated