Ethyl Acetate → 2-[3-(3-Fluorophenyl)-1H-5-indazolyl]acetic Acid

HRID 503121Notes

Reaction equation

HRID 503121 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14](CC#N)[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:20]([O:23]CC)(=[O:22])[CH3:21]>O.S(=O)(=O)(O)O>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([CH2:21][C:20]([OH:23])=[O:22])[CH:15]=3)[NH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 8857Ethyl AcetateHCID 222606222-(3-(3-Fluorophenyl)-1H-5-indazolyl]acetonitrile

Product 1

HCID 222610132-[3-(3-Fluorophenyl)-1H-5-indazolyl]acetic Acid

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1118Sulfuric AcidSolvent

Procedure

50 mg of 2-[3-(3-fluorophenyl)-1H-5-indazolyl]acetonitrile was suspended in 0.5 ml of water and 0.4 ml of concentrated sulfuric acid, and the suspension was stirred at 95° C. for 2 hours. The reaction mixture was added with 20 ml of ethyl acetate, sequentially washed with water (×2) and brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 48 mg of the title compound as pale red crystals.

Workup

  1. washsequentially washed with water (×2) and brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-e7571b845a8e4a8c84401713c1543ae1
Source dataset
uspto-grants-2010_08
Patent number
US07776890B2

Reaction notes

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