反应详情

To a solution of 300 mg of tert-butyl 5-(aminomethyl)-3-(3-fluorophenyl)-1H-1-indazolecarboxylate in 1 ml methylene chloride was added 2 ml of trifluoroacetic acid, and the mixture was stirred at room temperature for 6.5 hours. After removing the solvent by filtration, to the residue was added 20 ml of ethyl acetate. The mixture was sequentially washed with saturated aqueous sodium hydrogencarbonate solution (×2) and brine, dried over anhydrous magnesium sulfate and the solvent was evaporated, to give 188 mg of the title compound as yellow crystals.

1. customAfter removing the solvent
2. filtrationby filtration
3. additionto the residue was added 20 ml of ethyl acetate
4. washThe mixture was sequentially washed with saturated aqueous sodium hydrogencarbonate solution (×2) and brine
5. dry with materialdried over anhydrous magnesium sulfate
6. customthe solvent was evaporated