HCID 22260898, compound → HCID 22260893, compound

HRID 503177Notes

Reaction equation

HRID 503177 reaction equation
[Br:1][C:2]1[C:3]([O:21][CH3:22])=[C:4]([CH:9]([C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=2)[OH:10])[C:5]([F:8])=[CH:6][CH:7]=1>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Br:1][C:2]1[C:3]([O:21][CH3:22])=[C:4]([C:9]([C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=2)=[O:10])[C:5]([F:8])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 22260898HCID 22260898, compound

Product 1

HCID 22260893HCID 22260893, compoundYield 95.3%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 1.72 g of (3-bromo-6-fluoro-2-methoxy-phenyl)-naphthalen-2-yl-methanol in 34.4 ml methylene chloride was added 5.16 g of activated manganese dioxide, followed by stirring at room temperature for 17 hours. Then, the manganese dioxide was filtered off through Celite. The solvent was removed by distillation, to give 1.63 g of the title compound as a yellow oil.

Workup

  1. filtrationThen, the manganese dioxide was filtered off through Celite
  2. customThe solvent was removed by distillation

Sources & evidence

ORD record
ord-bbdb8fa6ec564c82abb11b6440bc7ef4
Source dataset
uspto-grants-2010_08
Patent number
US07776890B2

Reaction notes

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