反应详情

To a solution of 2-amino-3-(3,3-dimethylbut-1-ynyl)-5-nitrobenzonitrile (1.7 g, 7.0 mmol) in THF (35 mL) was added TBAF (9.5 g, 28 mmol) at room temperature. The mixture was heated at reflux overnight. The reaction mixture was cooled and the THF was removed under reduced pressure. Water (50 ml) was added to the residue and the mixture was extracted with EtOAc. The organics were dried over Na2SO4 and the solvent was evaporated under vacuum to obtain 0.87 g of crude product 2-tert-butyl-5-nitro-1H-indole-7-carbonitrile which was used directly in the next step without purification.

1. temperatureThe mixture was heated
2. temperatureat reflux overnight
3. temperatureThe reaction mixture was cooled
4. customthe THF was removed under reduced pressure
5. additionWater (50 ml) was added to the residue
6. extractionthe mixture was extracted with EtOAc
7. dry with materialThe organics were dried over Na2SO4
8. customthe solvent was evaporated under vacuum