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HRID50342

反应详情

EQUATION

反应方程式

HRID 50342 的结构方程式

REACTANTS

反应物

4
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCO
HCID702

Ethanol

C2H6O

结构：O=C([O-])[O-].[NH4+].[NH4+]
HCID517111

Ammonium carbonate

CH8N2O3

结构：C#CCN(CCC(=O)OCC)C(=O)c1ccc2c(c1)nc(CNc1ccc(C#N)cc1)n2C
HCID18412640

未命名化合物

PRODUCTS

生成物

1
结构：C#CCN(CCC(=O)OCC)C(=O)c1ccc2c(c1)nc(CNc1ccc(C(=N)N)cc1)n2C.Cl
HCID18412720

未命名化合物

收率 81%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO.ClCCl
溶剂HCID21584144

Dichloromethane ethanol

C3H8Cl2O

PROCEDURE

实验过程

Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-propargyl-N-(2-ethoxycarbonylethyl)amide, ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 81% of theory, C25H28N6O3 (460.6); Rf value: 0.094 (silica gel; dichloromethane/ethanol=4:1); EKA mass spectrum: (M+H)+=461; (M+H+Na)++=242; (M+2H)++=231.