反应详情

7-Bromo-1,5-naphthyridin-4-ol (7.0 g) and phosphoryl chloride (200 mL) were refluxed for 5 h in a RBF fitted with a reflux condenser. Excess POCl3 was distilled off under reduced pressure and the residue poured onto ice. This cold mixture was carefully neutralized with aq. ammonia, which caused an exotherm. The resulting solid was filtered, washed with water and dried. The product was recrystallized from n-heptane to give white needles of 3-bromo-8-chloro-1,5-naphthyridine.

1. customfitted with a reflux condenser
2. distillationExcess POCl3 was distilled off under reduced pressure
3. additionthe residue poured onto ice
4. filtrationThe resulting solid was filtered
5. washwashed with water
6. customdried
7. customThe product was recrystallized from n-heptane