Hydrochloric Acid → HCID 18412608, compound

HRID 50352Notes

Reaction equation

HRID 50352 reaction equation
[CH2:1]([NH:8][C:9]([C:11]1[CH:30]=[CH:29][C:14]2[N:15]([CH3:28])[C:16]([CH2:18][NH:19][C:20]3[CH:25]=[CH:24][C:23]([C:26]#[N:27])=[CH:22][CH:21]=3)=[N:17][C:13]=2[CH:12]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:31].C(O)C.C(=O)([O-])[O-].[NH4+:39].[NH4+]>ClCCl.C(O)C>[ClH:31].[CH2:1]([NH:8][C:9]([C:11]1[CH:30]=[CH:29][C:14]2[N:15]([CH3:28])[C:16]([CH2:18][NH:19][C:20]3[CH:21]=[CH:22][C:23]([C:26](=[NH:39])[NH2:27])=[CH:24][CH:25]=3)=[N:17][C:13]=2[CH:12]=1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 517111Ammonium CarbonateHCID 184127301-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-benzylamide

Product 1

HCID 18412608HCID 18412608, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-benzylamide, ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 63% of theory, C24H24N6O (412.5); Rf value: 0.76 (silica gel; dichloromethane/ethanol=4:1); EKA mass spectrum: (M+H)+=413.

Sources & evidence

ORD record
ord-d7e96585ee2a447ca49fca42e3ac633d
Source dataset
uspto-grants-2004_03
Patent number
US06710055B2

Reaction notes

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