Hydrochloric Acid → HCID 18412390, compound

HRID 50353Notes

Reaction equation

HRID 50353 reaction equation
[C:1]1([N:7]([CH2:30]CC(OC)=O)[C:8]([C:10]2[CH:11]=[C:12]3[N:18]=[C:17]([CH2:19][S:20][C:21]4[CH:26]=[CH:25][C:24]([C:27]#[N:28])=[CH:23][CH:22]=4)[N:16]([CH3:29])[C:13]3=[N:14][CH:15]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:36].C(=O)([O-])[O-].[NH4+:41].[NH4+].[C:43]([O:46][CH2:47][CH3:48])(=[O:45])[CH3:44].C(O)C.N>C(O)C>[ClH:36].[C:1]1([N:7]([CH2:30][CH2:44][C:43]([O:46][CH2:47][CH3:48])=[O:45])[C:8]([C:10]2[CH:11]=[C:12]3[N:18]=[C:17]([CH2:19][S:20][C:21]4[CH:22]=[CH:23][C:24]([C:27](=[NH:28])[NH2:41])=[CH:25][CH:26]=4)[N:16]([CH3:29])[C:13]3=[N:14][CH:15]=2)=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 517111Ammonium CarbonateHCID 18412655HCID 18412655, compoundHCID 86587043Ethyl acetate ethanol ammonia

Product 1

HCID 18412390HCID 18412390, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 1 from 3-methyl-2-[(4-cyanophenyl)thiomethyl]imidazo[4,5-b]pyridin-6-yl-carboxylic acid-N-phenyl-N-(2-methoxycarbonylethyl)amide, ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 88% of theory, C27H28N6O3S (516.63); Rf value: 0.23 (silica gel; ethyl acetate/ethanol/ammonia=50:45:5); EKA mass spectrum: (M+H)+=517; (M+H+Na)++=270.

Sources & evidence

ORD record
ord-5ea9f7c83c2347fba7b0305cd5780c26
Source dataset
uspto-grants-2004_03
Patent number
US06710055B2

Reaction notes

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