Hexane → HCID 178516446, compound

HRID 503581Notes

Reaction equation

HRID 503581 reaction equation
CC1(C)O[C:6](=[O:8])[C:5](=[CH:9][NH:10][C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)C(=O)O1.CCCCCC>C1(OC2C=CC=CC=2)C=CC=CC=1>[N:10]1[C:11]2[C:12](=[CH:13][N:14]=[CH:15][CH:16]=2)[C:6]([OH:8])=[CH:5][CH:9]=1

Participants

4

Reactant 2

HCID 8058HexaneHCID 59427333HCID 59427333, compound

Product 1

HCID 178516446HCID 178516446, compound

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

A solution of 2,2-dimethyl-5-((pyridin-4-ylamino)methylene)-1,3-dioxane-4,6-dione (1.149 g, 4.63 mmol) in diphenyl ether was heated at 200° C. for 20 min, then cooled to RT. Hexane was added and the mixture was stirred at RT for 30 mins. The solid was filtered off and washed with hexane to furnish 1,6-naphthyridin-4-ol as an off-brown solid.

Workup

  1. filtrationThe solid was filtered off
  2. washwashed with hexane

Sources & evidence

ORD record
ord-3f1d461f44504da29f96b66df178b6fe
Source dataset
uspto-grants-2010_08
Patent number
US07776857B2

Reaction notes

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