Hydrochloric Acid → HCID 18412574, compound

HRID 50360Notes

Reaction equation

HRID 50360 reaction equation
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([S:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH2:16][CH2:15]3)(=[O:13])=[O:12])=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:23][NH:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]#[N:32])=[CH:27][CH:26]=1.[ClH:33].C(O)C.C(=O)([O-])[O-].[NH4+:41].[NH4+]>ClCCl.CO>[ClH:33].[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([S:11]([N:14]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH2:16][CH2:15]3)(=[O:12])=[O:13])=[CH:10][C:5]=2[N:4]=[C:3]1[CH2:23][NH:24][C:25]1[CH:26]=[CH:27][C:28]([C:31](=[NH:41])[NH2:32])=[CH:29][CH:30]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 517111Ammonium CarbonateHCID 18412607HCID 18412607, compound

Product 1

HCID 18412574HCID 18412574, compoundYield 15%

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 25d from 1-methyl-2-[N-(4-cyanophenyl)aminomethyl]-5-(2,3-dihydroindol-1-yl-sulfonyl)benzimidazole and ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 15% of theory, C24H24N6O2S (460.6); Rf value: 0.36 (silica gel; dichloromethane/methanol=4:1); EKA mass spectrum: (M+H)+=461.

Sources & evidence

ORD record
ord-0457bab168d8459bab808016b91c28a0
Source dataset
uspto-grants-2004_03
Patent number
US06710055B2

Reaction notes

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