Phosphorus tribromide → 7-[4-(1-Bromoethyl)phenyl]-6-phenylimidazo[1,2-a]pyrimidine

HRID 503746노트

반응식

HRID 503746 반응식
[C:1]1([C:7]2[C:8]([C:16]3[CH:21]=[CH:20][C:19]([CH:22](O)[CH3:23])=[CH:18][CH:17]=3)=[N:9][C:10]3[N:11]([CH:13]=[CH:14][N:15]=3)[CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Br)(Br)[Br:26]>ClCCl>[Br:26][CH:22]([C:19]1[CH:20]=[CH:21][C:16]([C:8]2[C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[CH:12][N:11]3[CH:13]=[CH:14][N:15]=[C:10]3[N:9]=2)=[CH:17][CH:18]=1)[CH3:23]

참가 물질

4

반응물 2

HCID 24614Phosphorus tribromideHCID 684592251-[4-(6-Phenylimidazo[1,2-a]pyrimidin-7-yl)phenyl]ethanol

생성물 1

HCID 684610867-[4-(1-Bromoethyl)phenyl]-6-phenylimidazo[1,2-a]pyrimidine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

100 mg of the product of step 1 are dissolved in dichloromethane, cooled to 0° C. and 86 mg PBr3 are added. The mixture is stirred at room temperature for 24 h. Ice is added, the mixture extracted with dichloromethane and water, the organic layer are dried over Na2SO4 and the solvent is evaporated.

후처리

  1. additionIce is added
  2. extractionthe mixture extracted with dichloromethane and water
  3. dry with materialthe organic layer are dried over Na2SO4
  4. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-3c03ba2dc44548c5ae78c7e5da63dd66
출처 데이터셋
uspto-grants-2010_08
특허 번호
US07776864B2

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