反应详情

250 mg of the product of step 1 and 10 ml POCl3 are heated to 100° C. for 1 h. The excess POCl3 is removed by distillation and the residue is treated with ice and diluted with dichloromethane. The phases are separated, the aqueous layer is extracted twice with dichloromethane, the combined organic layers are dried over Na2SO4 and concentrated to give the crude product.

1. customThe excess POCl3 is removed by distillation
2. additionthe residue is treated with ice
3. additiondiluted with dichloromethane
4. customThe phases are separated
5. extractionthe aqueous layer is extracted twice with dichloromethane
6. dry with materialthe combined organic layers are dried over Na2SO4
7. concentrationconcentrated