N,N-Dimethylaniline → HCID 86630683, compound

HRID 503773Notes

Reaction equation

HRID 503773 reaction equation
[CH3:1][C:2]1[N:18]=[C:5]2[N:6]=[C:7](O)[C:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[C:9]([CH3:10])[N:4]2[N:3]=1.CN(C)C1C=CC=CC=1.O=P(Cl)(Cl)[Cl:30]>>[Cl:30][C:7]1[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:9]([CH3:10])[N:4]2[N:3]=[C:2]([CH3:1])[N:18]=[C:5]2[N:6]=1

Participants

4

Reactant 3

HCID 949N,N-DimethylanilineHCID 24813Phosphorus oxychlorideHCID 178432406HCID 178432406, compound

Product 1

HCID 86630683HCID 86630683, compound

Conditions

Temperature
100 °C

Procedure

1.34 g of the product of step 1 are suspended in 20 ml POCl3. 1.06 ml N,N-dimethylaniline is added and the mixture is heated to 100° C. for 45 min. The excess of POCl3 is removed by distillation and the residue is treated with ice. The desired product precipitates and is collected by filtration.

Workup

  1. customThe excess of POCl3 is removed by distillation
  2. additionthe residue is treated with ice
  3. customThe desired product precipitates
  4. filtrationis collected by filtration

Sources & evidence

ORD record
ord-dfd3c281bc894002b6125d9f39b5759b
Source dataset
uspto-grants-2010_08
Patent number
US07776864B2

Reaction notes

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