Hydrochloric Acid → HCID 178432373, compound

HRID 503781Notes

Reaction equation

HRID 503781 reaction equation
[CH3:1][C:2]1[N:40]=[C:5]2[N:6]=[C:7]([C:16]3[CH:21]=[CH:20][C:19]([CH2:22][N:23]4[CH2:28][CH2:27][CH:26]([C:29]5[N:33]=[C:32]([C:34]6[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=6)[NH:31][N:30]=5)[CH2:25][CH2:24]4)=[CH:18][CH:17]=3)[C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:9][N:4]2[N:3]=1.[ClH:41]>CO>[ClH:41].[CH3:1][C:2]1[N:40]=[C:5]2[N:6]=[C:7]([C:16]3[CH:17]=[CH:18][C:19]([CH2:22][N:23]4[CH2:24][CH2:25][CH:26]([C:29]5[N:33]=[C:32]([C:34]6[CH:39]=[CH:38][CH:37]=[CH:36][N:35]=6)[NH:31][N:30]=5)[CH2:27][CH2:28]4)=[CH:20][CH:21]=3)[C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:9][N:4]2[N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178432372HCID 178432372, compound

Product 1

HCID 178432373HCID 178432373, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 8.79 g 2-methyl-6-phenyl-5-(4-{[4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)[1,2,4]triazolo[1,5-a]pyrimidine (prepared as described under example 37) in 88 ml methanol are added 2.85 ml hydrochloric acid solution (5.84N in methanol). The mixture is stirred at room temperature for 1 h. The solvent is removed to yield the desired product.

Workup

  1. customThe solvent is removed

Sources & evidence

ORD record
ord-7e917270dad749ba86ac46d51ce6b4a0
Source dataset
uspto-grants-2010_08
Patent number
US07776864B2

Reaction notes

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