Hydrochloric Acid → HCID 178478299, compound

HRID 503783Notes

Reaction equation

HRID 503783 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[N:18]=[C:17]([C:19]3[S:20][CH:21]=[CH:22][N:23]=3)[NH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24].CO>O1CCOCC1>[ClH:24].[S:20]1[CH:21]=[CH:22][N:23]=[C:19]1[C:17]1[NH:16][N:15]=[C:14]([CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:18]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178451829HCID 178451829, compound

Product 1

HCID 178478299HCID 178478299, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The mixture of 7.59 g of the crude product obtained in step 4 is dissolved in dioxane and 68 ml hydrogen chloride 4M sol. in dioxane is added slowly. The product appears as an oil. After addition of 542 ml methanol the oil is dissolved. The solution is stirred over night until precipitation of the crystalline product.

Workup

  1. dissolutionis dissolved

Sources & evidence

ORD record
ord-19c331a2b0484616b995c16427a057fb
Source dataset
uspto-grants-2010_08
Patent number
US07776864B2

Reaction notes

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