Hydrochloric Acid → HCID 178432378, compound

HRID 503785Notes

Reaction equation

HRID 503785 reaction equation
[ClH:1].[CH3:2][C:3]1[N:40]=[C:6]2[N:7]=[C:8]([C:17]3[CH:22]=[CH:21][C:20]([CH2:23][N:24]4[CH2:29][CH2:28][CH:27]([C:30]5[N:34]=[C:33]([C:35]6[S:36][CH:37]=[CH:38][N:39]=6)[NH:32][N:31]=5)[CH2:26][CH2:25]4)=[CH:19][CH:18]=3)[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[CH:10][N:5]2[N:4]=1>CO>[ClH:1].[CH3:2][C:3]1[N:40]=[C:6]2[N:7]=[C:8]([C:17]3[CH:22]=[CH:21][C:20]([CH2:23][N:24]4[CH2:29][CH2:28][CH:27]([C:30]5[N:34]=[C:33]([C:35]6[S:36][CH:37]=[CH:38][N:39]=6)[NH:32][N:31]=5)[CH2:26][CH2:25]4)=[CH:19][CH:18]=3)[C:9]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)=[CH:10][N:5]2[N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid3×HCID 178432377HCID 178432377, compound

Product 1

HCID 178432378HCID 178432378, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The hydrochloride can be obtained by adding to a solution of 2-Methyl-6-phenyl-5-[4-({4-[5-(1,3-thiazol-2-yl)-1H-1,2,4-triazol-3-yl]piperidin-1-yl}methyl)phenyl][1,2,4]-triazolo[1,5-a]pyrimidine in methanol an adequate amount of hydrochloric acid solution (5.84N in methanol). After stirring for 1 h the hydrochloride can be filtered and dried.

Workup

  1. filtrationcan be filtered
  2. customdried

Sources & evidence

ORD record
ord-ed43a7c8333b481da426b01182588707
Source dataset
uspto-grants-2010_08
Patent number
US07776864B2

Reaction notes

Loading…