HCID 140409624, compound → HCID 140409614, compound

HRID 50389Notes

Reaction equation

HRID 50389 reaction equation
[C:1]1([N:7]([CH2:40][CH2:41][CH2:42][O:43]CC2C=CC=CC=2)[C:8]([C:10]2[CH:39]=[CH:38][C:13]3[N:14]([CH3:37])[C:15]([CH2:17][NH:18][C:19]4[CH:24]=[CH:23][C:22]([C:25](=[NH:36])[NH:26][C:27]([O:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[O:28])=[CH:21][CH:20]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>ClCCl.C(O)C>[C:1]1([N:7]([CH2:40][CH2:41][CH2:42][OH:43])[C:8]([C:10]2[CH:39]=[CH:38][C:13]3[N:14]([CH3:37])[C:15]([CH2:17][NH:18][C:19]4[CH:24]=[CH:23][C:22]([C:25](=[NH:36])[NH:26][C:27]([O:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])=[O:28])=[CH:21][CH:20]=4)=[N:16][C:12]=3[CH:11]=2)=[O:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 1

HCID 140409624HCID 140409624, compound

Product 1

HCID 140409614HCID 140409614, compoundYield 26%

Reagents, catalysts & solvents 1

HCID 21584144Dichloromethane ethanolSolvent

Procedure

Prepared analogously to Example 165 from 1-methyl-2-[N-[4-(N-n-hexyloxycarbonylamidino)phenyl]aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(3-benzyloxy-n-propyl)amide by catalytic debenzylation. Yield: 26% of theory, C33H40N6O4 (584.7); Rf value: 0.39 (silica gel; dichloromethane/ethanol=9:1); EKA mass spectrum: (M+H)+=585; (M+H+Na)++=304; (M+Na)+=607.

Sources & evidence

ORD record
ord-d4a6d00089214e86860bb24c81308b39
Source dataset
uspto-grants-2004_03
Patent number
US06710055B2

Reaction notes

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