HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(3-Methoxy-4-pyrrolidin-3-yl-benzenesulfonyl)-benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-[4-(2-Cyano-benzenesulfonyl)-2-methoxy-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester | HCID 59428326 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(3-Methoxy-4-pyrrolidin-3-yl-benzenesulfonyl)-benzonitrile | HCID 24984166 | — |
Reaction Steps
3-[4-(2-Cyano-benzenesulfonyl)-2-methoxy-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester was deprotected following the procedure described in Example 1. The free amine base was converted in the corresponding hydrochloride salt by addition of a small excess of HCl in 1,4-dioxane: MP=247.8-249.1° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07776910B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-932b9d28bdaf46c68562f6892ecdcfe7 |
| Source note | uspto-grants-2010_08 |