Hydrochloric Acid → 2-(3-Methoxy-4-pyrrolidin-3-yl-benzenesulfonyl)-benzonitrile

HRID 503937Notes

Reaction equation

HRID 503937 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([C:13]2[CH:18]=[CH:17][C:16]([S:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=3[C:28]#[N:29])(=[O:21])=[O:20])=[CH:15][C:14]=2[O:30][CH3:31])[CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[CH3:31][O:30][C:14]1[CH:15]=[C:16]([S:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[C:28]#[N:29])(=[O:21])=[O:20])[CH:17]=[CH:18][C:13]=1[CH:10]1[CH2:11][CH2:12][NH:8][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 594283263-[4-(2-Cyano-benzenesulfonyl)-2-methoxy-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 249841662-(3-Methoxy-4-pyrrolidin-3-yl-benzenesulfonyl)-benzonitrile

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-[4-(2-Cyano-benzenesulfonyl)-2-methoxy-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester was deprotected following the procedure described in Example 1. The free amine base was converted in the corresponding hydrochloride salt by addition of a small excess of HCl in 1,4-dioxane: MP=247.8-249.1° C.

Sources & evidence

ORD record
ord-932b9d28bdaf46c68562f6892ecdcfe7
Source dataset
uspto-grants-2010_08
Patent number
US07776910B2

Reaction notes

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