HRID503938

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=S(=O)(c1ccccc1)n1cc(Br)c2cc(F)ccc21

HCID59428349

未命名化合物

HCID59428384

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(Sc2cn(S(=O)(=O)c3ccccc3)c3ccc(F)cc23)ccc1C1CCN(C(=O)OC(C)(C)C)C1

HCID59428404

未命名化合物

PROCEDURE

实验过程

3-(4-Mercapto-2-methyl-phenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester was reacted with 1-benzenesulfonyl-3-bromo-5-fluoro-1H-indole using the procedure of step 1 of Example 3 to provide 3-[4-(1-Benzenesulfonyl-5-fluoro-1H-indol-3-ylsulfanyl)-2-methyl-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b360edb57f1c43e3b5c215fabeff1676
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07776910B2
来源说明: uspto-grants-2010_08

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([C:13]2[CH:18]=[CH:17][C:16]([SH:19])=[CH:15][C:14]=2[CH3:20])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:21]1([S:27]([N:30]2[C:38]3[C:33](=[CH:34][C:35]([F:39])=[CH:36][CH:37]=3)[C:32](Br)=[CH:31]2)(=[O:29])=[O:28])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH:10]([C:13]2[CH:18]=[CH:17][C:16]([S:19][C:32]3[C:33]4[C:38](=[CH:37][CH:36]=[C:35]([F:39])[CH:34]=4)[N:30]([S:27]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)(=[O:29])=[O:28])[CH:31]=3)=[CH:15][C:14]=2[CH3:20])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]