Hydrochloric Acid → HCID 66877421, compound

HRID 503951Notes

Reaction equation

HRID 503951 reaction equation
[ClH:1].C(OC([N:9]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([C:23]3[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[CH:24]=3)(=[O:22])=[O:21])=[CH:16][C:15]=2[O:30][CH2:31][CH2:32][OH:33])[CH2:10]1)=O)(C)(C)C>O1CCOCC1>[ClH:1].[F:29][C:25]1[CH:24]=[C:23]([S:20]([C:17]2[CH:18]=[CH:19][C:14]([CH:11]3[CH2:12][CH2:13][NH:9][CH2:10]3)=[C:15]([CH:16]=2)[O:30][CH2:31][CH2:32][OH:33])(=[O:21])=[O:22])[CH:28]=[CH:27][CH:26]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66877289HCID 66877289, compound

Product 1

HCID 66877421HCID 66877421, compoundYield 94.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of HCl (4 M in 1,4-dioxane, 0.3 mL, 1.2 mmol) was added to a solution of 3-[4-(3-fluoro-benzenesulfonyl)-2-(2-hydroxy-ethoxy)-phenyl]-pyrrolidine-1-carboxylic acid tert-butyl ester (100 mg, 0.215 mmol) in 1,4-dioxane (1 mL) under nitrogen atmosphere. The reaction mixture was stirred for 4 hours The solvent was then evaporated under reduced pressure to give 82 mg of 2-[5-(3-fluoro-benzenesulfonyl)-2-pyrrolidin-3-yl-phenoxy]-ethanol hydrochloride as a foam. MS (M+H)=366.

Workup

  1. customwas then evaporated under reduced pressure

Sources & evidence

ORD record
ord-edeb442735154d91995a8557cd3a0e6c
Source dataset
uspto-grants-2010_08
Patent number
US07776910B2

Reaction notes

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