Ammonium Hydroxide → HCID 59428377, compound

HRID 503956Notes

Reaction equation

HRID 503956 reaction equation
[OH-].[NH4+:2].CO[C:5](=[O:29])[CH2:6][N:7]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:17]=[CH:16][C:15]([S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[CH:22]=3)(=[O:20])=[O:19])=[CH:14][C:13]=2[CH3:28])[CH2:8]1>CO>[F:27][C:23]1[CH:22]=[C:21]([S:18]([C:15]2[CH:16]=[CH:17][C:12]([CH:9]3[CH2:10][CH2:11][N:7]([CH2:6][C:5]([NH2:2])=[O:29])[CH2:8]3)=[C:13]([CH3:28])[CH:14]=2)(=[O:20])=[O:19])[CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 59428402HCID 59428402, compound

Product 1

HCID 59428377HCID 59428377, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A concentrated solution of ammonium hydroxide (2 mL) was added to a solution of {3-[4-(3-fluoro-benzenesulfonyl)-2-methyl-phenyl]-pyrrolidin-1-yl}-acetic acid methyl ester (130 mg, 0.3321 mmol) in methanol (2 mL) and the resulting mixture was stirred at room temperature for 16 hours. Solvent was evaporated under reduced pressure and the crude material was purified via flash chromatography (DCM/MeOH/NH4OH) to give 0.102 g of 2-{3-[4-(3-fluoro-benzenesulfonyl)-2-methyl-phenyl]-pyrrolidin-1-yl}-acetamide of a white foam: MS (M+H)=377.

Workup

  1. customSolvent was evaporated under reduced pressure
  2. customthe crude material was purified via flash chromatography (DCM/MeOH/NH4OH)

Sources & evidence

ORD record
ord-5aef839e8fb041cfbaea96a520d0f8bd
Source dataset
uspto-grants-2010_08
Patent number
US07776910B2

Reaction notes

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