Sodium Hydroxide → HCID 18412381, compound

HRID 50404Notes

Reaction equation

HRID 50404 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:32][CH2:33][C:34]([O:36]CC)=[O:35])[C:9]([C:11]1[CH:31]=[CH:30][C:14]2[N:15]([CH3:29])[C:16]([CH2:18][NH:19][C:20]3[N:21]=[CH:22][C:23]([C:26](=[NH:28])[NH2:27])=[N:24][CH:25]=3)=[N:17][C:13]=2[CH:12]=1)=[O:10].[OH-].[Na+]>CO>[N:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]([CH2:32][CH2:33][C:34]([OH:36])=[O:35])[C:9]([C:11]1[CH:31]=[CH:30][C:14]2[N:15]([CH3:29])[C:16]([CH2:18][NH:19][C:20]3[N:21]=[CH:22][C:23]([C:26](=[NH:27])[NH2:28])=[N:24][CH:25]=3)=[N:17][C:13]=2[CH:12]=1)=[O:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18412599HCID 18412599, compound

Product 1

HCID 18412381HCID 18412381, compoundYield 11%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogously to Example 26 from 1-methyl-2-[N-(2-amidinopyrazin-5-yl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-(2-pyridyl)-N-(2-ethoxycarbonylethyl)amide hydrochloride and sodium hydroxide solution. Yield: 11% of theory, C23H23N9O3 (473.5); Rf value: 0.55 (Reversed Phase silica gel RP-8; 5% saline solution/methanol=6:4); EKA mass spectrum: (M+H)+=474; (M+H+Na)+=496.6.

Sources & evidence

ORD record
ord-acc29eafd4c541978942016f69aa6527
Source dataset
uspto-grants-2004_03
Patent number
US06710055B2

Reaction notes

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