HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lovastatin → Lovastatin Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lovastatin | HCID 53232 | — |
| Reactant | 3,5-Dihydroxypentanoic acid | HCID 322588 | — |
| Product | Lovastatin Acid | HCID 64727 | — |
Reaction Steps
For example, lovastatin (Ia) is prepared by lactonisation of the 3,5-dihydroxy pentanoic acid derivative (II) to (Ia) either by heating in an organic solvent or in the presence of an acid catalyst. The former, viz. mevinolinic acid, is obtained from a fermentation broth containing Asperigillus Terreus.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07777056B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-5c4d68f7bdef48c8b8ecd2e2f3a1a222 |
| Source note | uspto-grants-2010_08 |